SCIENTIFIC PROGRAM

Glomerular Diseases: Genetics & Gene Regulation

Moderators: Dr. Matt Sampson, MD, MSCE, Boston Children's Hospital/Harvard University/Broad Institute; Dr. Hermann Pavenstädt, Westfälische Wilhelms-Universität Münster

• Genetic epidemiology to understand kidney functions and disease - Prof. Anna Köttgen, MD, MPH, University of Freiburg
• From mapping to mechanism to medicine - Dr. Katalin Susztak, MD, PhD, University of Pennsylvania

• Spatial transcriptomics of DKD - Dr. Bernhard Dumoulin, MD, University of Pennsylvania 

Podocyte Basics & Glomerular Biology: Proteome & Metabolome Regulation

Moderators: Dr. Fabian Braun, MD, University Medical Center Hamburg-Eppendorf (UKE); Prof. Dr. Nicole Endlich, MD, PhD, University of Greifswald

• Metabolites - Dr. Markus Rinschen, MD, Aarhus University
• The intricacies of podocyte waste removal - Prof. Catherine Meyer-Schwesinger, MD, University Medical Center Hamburg-Eppendorf (UKE) 
• Mitochondria & aging - Dr. Mariya T. Sweetwyne, PhD, University of Washington

Podocyte Basics & Glomerular Biology: Systems Medicine & Disease Modeling

Moderators: Prof. Rafael Kramann, MD, PhD, RWTH Aachen; Prof. Dr. Jochen Reiser, MD, PhD, University of Texas Medical Branch

• Imaging & Disease Modeling - Dr. Paola Romagnani, MD, PhD, Meyer Children's Hospital Florence
• Single cell omics and systems biology - Prof. Julio Saez-Rodriguez, PhD, European Bioinformatics Institute
• Podocyte damage score - Prof. Dr. Andreas Beyer, PhD, University of Cologne
• Nephrocytes - Dr. Sybille Köhler, PhD, University Medical Center Hamburg-Eppendorf (UKE)
   

Glomerular Disease: IgA Nephropathy

Moderators: Dr. Liz Lightstone, PhD, FRCP,  FISN, Imperial College London; Dr. Hong Zhang, MD, PhD, Peking University

• IgAN genetics and omics - Dr. Krzysztof Kiryluk, MD, MS, Columbia University
• Experimental medicine studies in IgAN - Dr. Chee Kay Cheung, MBChB, PhD, University of Leicester
• Emerging concepts of IgA nephropathy therapy  - Prof. Jonathan Barratt, PhD, FRCP, University of Leicester

Primary Podocytopathies: Minimal Change Disease and FSGS

Moderators: Dr. Astrid Weins, MD, PhD, Brigham Women's Hospital; Prof. Dr. Thomas Benzing, MD, FASN, University of Cologne 

• Introduction to Podocytopathy and Proteinuria -  Prof. Dr. Thomas Benzing, MD, FASN, University of Cologne 
• Slit diaphragm composition and structure - Prof. Dr. Florian Grahammer, MD, University Medical Center Hamburg-Eppendorf (UKE)
• Genetics and modifiers in FSGS - Dr. Simone Sanna-Cherchi, MD, Columbia University
• Anti-Nephrin Podocytopathy - Dr. Felicitas Hengel, MD, University Medical Center Hamburg-Eppendorf (UKE)

Glomerular basement membrane disease and membranous glomerulonephritis 

Moderators: Prof. Pierre Ronco, MD, PhD, Sorbonne Université; Dr. Jeffrey Miner, PhD, Washington University in St. Louis

• Structure and function of the GBM - Prof. Rachel Lennon, BMedSci, BMBS, PhD, FRCPCH, University of Manchester
• Challenges and paths forward - Dr. André Weinstock, PhD, Alport Syndrome Foundation
• Complement & B-cells targeting - Dr. Nicola Tomas, MD, University Medical Center Hamburg-Eppendorf (UKE)

Best abstracts in glomerular disease research 

Moderators: Dr. Alessia Fornoni, MD, PhD, University of Miami; Dr. Andrey Shaw, MD Genentech

Basement membrane turnover and circulating matrix in Alport syndrome - Rebecca Preston, Paediatric Nephrology, Royal Manchester Children’s Hospital, University of Manchester 

Macula densa control of glomerular tissue remodeling - Georgina Gyarmati, Physiology and Neuroscience, Keck School of Medicine, University of Southern California 

The kidney slit diaphragm resembles a fishnet pattern - Alexandra Birtasu, Institute for Biophysics, Buchmann Institute for Molecular Life Sciences, Johann Wolfgang Goethe-Universität 

Phospho-protein network associated with nephrin is essential for slit-diaphragm filtration and podocyte adhesion - Blanda Beci, Department of Nephrology, University Hospital Zurich, University of Zurich 

Targeting the BTLA-HVEM checkpoint as a treatment strategy in glomerulonephritis - Bastian Trinsch, Department II of Internal Medicine, University Hospital Cologne 

Podocyte derived endothelin-1 and crosstalk with endothelial cells through ETA is essential for glomerular injury - Ilse Daehn, Medicine - Nephrology, Icahn School of Medicine at Mount Sinai 

Late-breaking

Moderators: Dr. Shikha Wadhwani, MD, MS, FASN, University of Texas Medical Branch; Dr. Keisha Gibson MD, MPH, FASN, University of North Carolina at Chapel Hill

• PARASOL - Laura Mariani, University of Michigan
• Sibeprenlimab for patients with IgA Nephropathy: results from a prespecified interim analysis of the Phase 3 VISIONARY Study - Jonathan Barratt, University of Leicester
• VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or posttransplant recurrent C3G or primary (idiopathic) IC-MPGN - Carla M. Nester, University of Iowa
• Pathology-oriented multiplexing enables integrative disease mapping - Victor Puelles, University Medical Center Hamburg-Eppendorf & Aarhus University
• APOL1 bi- and monoallelic variants and chronic kidney disease in West Africans - Vincent Boima, University of Ghana Medical School
• Individual patient pathway coordination analysis in a cross-species single-cell kidney atlas - Konstantin Klötzer, Medical University of Graz

Included in registration

Emerging career highlights: selected short talks

Moderators: Dr. Linus Butt, MD, University of Cologne; Dr. Stuart Shankland, MD, MBA, University of Washington

• Resolving ARHGEF10 as an NCK2-mediated regulator of podocyte adhesion resiliency signaling - Alice Wang, Molecular and Cellular Biology, University of Guelph 
• Parietal epithelial proliferation is a key driver of molecular heterogeneity in IgAN and FSGS - Charlotte Boys, Institute for Computational Biomedicine, University of Heidelberg
• Functional and dynamic expression of apolipoprotein L1 risk variants at the plasma membrane drives haplotype-dependent cytotoxicity - Oyindamola Christiana Adebayo, Department of Cardiovascular Sciences, KU Leuven
• An ex-vivo model of ER stress in glomerular disease - Daniel Markett, Department of Molecular Nephrology, University Hospital Münster
• A novel therapeutic target on antibody-secreting cells for the treatment of antibody-mediated kidney diseases - Marie Eggers, III. Department of Medicine, University Medical Center Hamburg-Eppendorf
• Unequal contributions of YAP and TAZ to podocyte health and glomerular injury - Lioba Ester, Department II of Internal Medicine, University Medical Center Cologne

• Marilyn G. Farquhar Lifetime Research Achievement Award
• Wilhelm Kriz Early Career Research Achievement Award

Glomerular Diseases: C3 glomerulonephritis and complement-mediated glomerulopathies

Moderators: Prof. Sydney Tang, MD, PhD, University of Hong Kong; Dr. Carla Nester, MD, MSA, FASN University of Iowa

• Complementopathies - Prof. Dr. Christoph Licht, MD, University of Toronto
• Update on clinical trials in complement-mediated glomerulopathies - Dr. Marina Vivarelli, MD, Ospedale Pediatrico Bambino Gesù
• Primary MPGN and C3 Glomerulopathy: Insights from Big Data - Prof. Daniel Gale, PhD, University College London

Glomerular Diseases: ANCA-associated vasculitis, Lupus, and Parietal Epithelial Cells

Moderators: Dr. Brad Rovin, MD, FASN, FACP, The Ohio State University; Dr. Silke Brix, MD, MRCP, University of Manchester

• T-cell mediated inflammation - Prof. Ulf Panzer, MD, University Medical Center Hamburg-Eppendorf (UKE)
• Role of PECs & crescent formation - Prof. Pierre-Louis Tharaux, MD, PhD, Inserm

Keynote Lecture: Bench to Bedside

Prof. Agnes Fogo, Vanderbilt University Medical Center; Prof. Dr. Jochen Reiser, MD, PHD, University of Texas Medical Branch

• Keynote Speaker: Prof. Dr. Matthias Kretzler, MD, University of Michigan
• "From basic concepts to clinical application"

Tobias B. Huber, Conference Chair, President International Society of Glomerular Disease, Director III. Department of Medicine, University Medical Center Hamburg-Eppendorf  

• Announcement of abstract awards   
• Announcement of the next host of the 16th International Podocyte Conference in 2027. 
• Closing remarks